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PREPARATIONS AND PRINCIPAL INDICATIONS

Posted by Monica Saturday, December 26, 2009 0 comments

Hi guys, I want to share the health tips about Sulphadimidine. This is the sulphanamide of choice for general purposes as it combines effectiveness with low toxicity. Sulphadimidine is rapidly absorbed and relatively slowly excreted in the urine in a fairly soluble form. An effective concentration in the blood ca usually is maintained by administration every four to six hours. Sodium salts are available for intravenous and intramuscular administration if the patient is vomiting or comatose. Children tolerate relatively large doses at 1 year one-sixth of the adult dose, at 3 years one-third doses. At 1 year one-sixth of the adult dose, at 3 years one- third, at 6 years two-thirds and from 12 years onwards adult doses should be given. Palatable suspensions are available for administration to children. The principal indications for the use of sulphadimidine are as follows.

Sulphadimidine is given in an initial loading dose of 2-3g. followed by 1 g. four-hourly for the first 48 hours and six-hourly thereafter until three or four days after the pyrexia subsides. Penicillin is preferable in the elderly or if the infection is severe. Thanks guys.

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Disease commences as a mild blood stream infection

Posted by Monica Wednesday, December 16, 2009 0 comments

Hi guys. The disease commences as a mild blood stream infection and accordingly the clinical manifestations are gradual in onset and variable. The symptoms in order of free quench are sweating, weakness, headache, anorexia, pains in limbs and back, constipation, rigors, cough sore throat and joint pains. The spleen is palpable in about 20 per cent. Of cases and a variable rash occurs in about 10 per cent. The temperature characteristically shows undulations, during which febrile and afebrile periods alternate. In other cases the Pyrex may be continuous and sweating may be profuse. Untreated, the disease may last for a few days or continue for many moths, and in the latter case the patient often becomes extremely depressed or irritable. Neutropenia and lymphocytosis usually occur in the more severe case. Sub-acute arthritis of one or more joints may occur. The spine is often the site affected and occasionally radiological charges due to osteomyelitis of a verebra can be demonstrated. A paravertebral abscess, which is rare, may be distinguished from tuberculosis by the fact that there is less destruction of the intervertebral disc. The diagnosis of undulant fever can usually be confirmed by blood culture or by agglutination tests. Other conditions causing prolonged fever, such as tuberculosis, enteritis fever, and subacute bacterial endocarditis must be considered in differential diagnosis. Thanks guys.

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